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The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

Original publication

DOI

10.3109/13547500903186452

Type

Journal article

Journal

Biomarkers

Publication Date

02/2010

Volume

15

Pages

20 - 30

Keywords

Aged, Biomarkers, Case-Control Studies, DNA Adducts, Erythrocytes, Europe, Female, Glutathione, Humans, Leukocytes, Lung Neoplasms, Male, Middle Aged, Molecular Epidemiology, Motor Activity, Pilot Projects, Risk Factors, Smoking