A meta-analysis of GFR slope as a surrogate endpoint for kidney failure.
Inker LA., Collier W., Greene T., Miao S., Chaudhari J., Appel GB., Badve SV., Caravaca-Fontán F., Del Vecchio L., Floege J., Goicoechea M., Haaland B., Herrington WG., Imai E., Jafar TH., Lewis JB., Li PKT., Maes BD., Neuen BL., Perrone RD., Remuzzi G., Schena FP., Wanner C., Wetzels JFM., Woodward M., Heerspink HJL., CKD-EPI Clinical Trials Consortium None.
Glomerular filtration rate (GFR) decline is causally associated with kidney failure and is a candidate surrogate endpoint for clinical trials of chronic kidney disease (CKD) progression. Analyses across a diverse spectrum of interventions and populations is required for acceptance of GFR decline as an endpoint. In an analysis of individual participant data, for each of 66 studies (total of 186,312 participants), we estimated treatment effects on the total GFR slope, computed from baseline to 3 years, and chronic slope, starting at 3 months after randomization, and on the clinical endpoint (doubling of serum creatinine, GFR