OBJECTIVE: Liver fat associates with obesity-related metabolic disturbances and may precede incident diseases. Metabolomic profiles of liver fat in the UK Biobank were investigated. METHODS: Regression models assessed the associations between 180 metabolites and proton density liver fat fraction (PDFF) measured 5 years later through magnetic resonance imaging, as the difference (in SD units) of each log metabolite measure with 1-SD higher PDFF among those without chronic disease and not taking statins, and by diabetes and cardiovascular diseases. RESULTS: After accounting for confounders, multiple metabolites were associated positively with liver fat (p
Journal article
Obesity (Silver Spring)
04/2023
31
1121 - 1132
Humans, Cardiovascular Diseases, Biological Specimen Banks, Magnetic Resonance Imaging, Liver, Non-alcoholic Fatty Liver Disease, Triglycerides, Lipoproteins, HDL, United Kingdom, Lipoproteins, LDL