Stress During Pregnancy and the Development of Diseases in the offspring: A Systematic-Review and Meta-Analysis.
Caparros-Gonzalez RA., Torre-Luque ADL., Romero-Gonzalez B., Quesada-Soto JM., Alderdice F., Peralta-Ramírez MI.
OBJECTIVE: The goal of this systematic-review and meta-analysis was to assess whether high maternal stress during pregnancy is associated with the development of pediatric pathology. DESIGN: Epidemiological peer-reviewed studies published in English or Spanish assessing associations between maternal stress during pregnancy and psychiatric and medical diseases were selected. PARTICIPANTS: We retrieved 73,024 citations; 42 studies meeting inclusion criteria were assessed. Overall sample included 65,814,076 women. FINDINGS: Overall odds ratio for the development of a medical disease was OR=1.24 (CI95=1.11, 1.39), Z=3.85, p