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Background and purposeDisabling anxiety affects a quarter of stroke survivors but access to treatment is poor. We developed a telemedicine model for delivering guided self-help cognitive behavioral therapy (CBT) for anxiety after stroke (TASK-CBT). We aimed to evaluate the feasibility of TASK-CBT in a randomized controlled trial workflow that enabled all trial procedures to be carried out remotely. In addition, we explored the feasibility of wrist-worn actigraphy sensor as a way of measuring objective outcomes in this clinical trial.MethodsWe recruited adult community-based stroke patients (n=27) and randomly allocated them to TASK-CBT (n=14) or relaxation therapy (TASK-Relax), an active comparator (n=13).ResultsIn our sample (mean age 65 [±10]; 56% men; 63% stroke, 37% transient ischemic attacks), remote self-enrolment, electronic signature, intervention delivery, and automated follow-up were feasible. All participants completed all TASK-CBT sessions (14/14). Lower levels of anxiety were observed in TASK-CBT when compared with TASK-Relax at both weeks 6 and 20. Mean actigraphy sensor wearing-time was 33 days (±15).ConclusionsOur preliminary feasibility data from the current study support a larger definitive clinical trial and the use of wrist-worn actigraphy sensor in anxious stroke survivors. Registration: URL: Unique identifier: NCT03439813.

Original publication




Journal article



Publication Date





2297 - 2306


Centre for Clinical Brain Sciences (H.Y.Y.C., A.J.C., M.S.D., G.E.M., W.N.W.), University of Edinburgh, UK.


Humans, Anxiety, Telemedicine, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Stroke, Relaxation Therapy, Actigraphy, Proof of Concept Study, Cognitive Behavioral Therapy