Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. METHODS: Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modelled using conditional logit regression analysis. RESULTS: Surveys from 1239 women (Australia: n=178; China: n=179; Denmark: n=88; Netherlands: n=177; Singapore: n=90; Sweden: n=178; UK: n=174; USA: n=175) were analysed. The key attribute affecting preferences was a test with the highest diagnostic yield (p<0.01). Women preferred tests with short turnaround times (p<0.01), and tests reporting variants of uncertain significance (VUS) (p<0.01) and secondary findings (SFs) (p<0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs. CONCLUSION: Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable. This article is protected by copyright. All rights reserved.

Original publication

DOI

10.1002/pd.6159

Type

Journal article

Journal

Prenat Diagn

Publication Date

27/04/2022