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Although we earlier reported a very poor outcome for younger adult patients with isocitrate dehydrogenase 2 (IDH2)R172 -mutated acute myeloid leukaemia (AML) entered into UK trials compared to IDH2WT and IDH2R140 -mutated patients, this was not corroborated by a study from the German-Austrian AML Study Group. We have therefore investigated a later cohort of IDH2-mutated patients to identify any changes in outcome and whether this could inform the optimal treatment for IDH2R172 AML. We found an improved outcome for IDH2R172 -mutated AML in the later trials and the data suggests that this may be due to the increased use of allogeneic transplantation to consolidate first remission.

Original publication




Journal article


Br J Haematol

Publication Date





1348 - 1352


acute myeloid leukaemia, allogeneic transplantation, isocitrate dehydrogenase 2 (IDH2)R172 mutations, optimal therapy, prognostic impact, Adult, Cohort Studies, Humans, Isocitrate Dehydrogenase, Leukemia, Myeloid, Acute, Mutation, Prognosis