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A recent study supports the concept that reduced kidney function causes higher blood pressure, but it found no evidence of causality in the opposite direction. We describe the method of bidirectional Mendelian randomization that was used to explore the direction of the causal relationship between kidney function and blood pressure, and examine the assumptions required for these analyses to give valid results.

Original publication

DOI

10.1016/j.kint.2020.05.048

Type

Journal article

Journal

Kidney Int

Publication Date

09/2020

Volume

98

Pages

547 - 549

Keywords

Blood Pressure, Causality, Humans, Kidney Diseases, Mendelian Randomization Analysis