Rheumatoid arthritis association at 6q23.
Thomson W., Barton A., Ke X., Eyre S., Hinks A., Bowes J., Donn R., Symmons D., Hider S., Bruce IN., Wellcome Trust Case Control Consortium None., Wilson AG., Marinou I., Morgan A., Emery P., YEAR Consortium None., Carter A., Steer S., Hocking L., Reid DM., Wordsworth P., Harrison P., Strachan D., Worthington J.
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).