Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women.
Clendenen TV., Ge W., Koenig KL., Afanasyeva Y., Agnoli C., Bertone-Johnson E., Brinton LA., Darvishian F., Dorgan JF., Eliassen AH., Falk RT., Hallmans G., Hankinson SE., Hoffman-Bolton J., Key TJ., Krogh V., Nichols HB., Sandler DP., Schoemaker MJ., Sluss PM., Sund M., Swerdlow AJ., Visvanathan K., Liu M., Zeleniuch-Jacquotte A.
CONTEXT: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies. OBJECTIVE: This study assessed whether risk factors for breast cancer are correlates of AMH concentration. METHODS: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population. RESULTS: Adjusting for age and cohort, AMH positively associated with age at menarche (P