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We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

Original publication

DOI

10.2807/1560-7917.ES.2018.23.27.1800323

Type

Journal article

Journal

Euro Surveill

Publication Date

07/2018

Volume

23

Keywords

antimicrobial resistance, antimicrobial treatment, whole-genome sequencing, gonorrhoea, treatment failure