Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. METHODS AND RESULTS: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. CONCLUSIONS: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.

Original publication

DOI

10.1161/CIRCGENETICS.108.833806

Type

Journal article

Journal

Circ Cardiovasc Genet

Publication Date

08/2009

Volume

2

Pages

322 - 328

Keywords

Adaptor Proteins, Signal Transducing, Adult, Aged, Chromosomes, Human, Pair 13, Electrocardiography, European Continental Ancestry Group, Female, Genome-Wide Association Study, Genotype, Heart Rate, Humans, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Receptors, G-Protein-Coupled