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Mammalian pregnancy is a unique immunologic situation in which the maternal immune system recognizes and accepts an antigenically disparate tissue, the conceptus. Currently, our understanding of human peri-implantation and early gestational events is largely based on animal studies, particularly mice. Although immune cells are present in the uterus before conception or blastocyst implantation, huge increases in immune cell numbers and the differentiation of specialized lymphocyte subsets are induced in species with hemochorial placentation during the process of decidualization.

Original publication

DOI

10.1542/neo.17-2-e93

Type

Journal article

Journal

NeoReviews

Publisher

American Academy of Pediatrics (AAP)

Publication Date

01/02/2016

Volume

17

Pages

e93 - e101